Multiple substudies will include specified investigational agents and combinations to be evaluated. CIVO stands for Comparative In Vivo Oncology. This is a multi-center, open-label Phase 0 Master Protocol designed to study the localized pharmacodynamics (PD) of anti-cancer therapies within the tumor microenvironment (TME) when administered intratumorally in microdose quantities via the CIVO device in patients with surface accessible solid tumors for which there is a scheduled surgical intervention. Why Should I Register and Submit Results?.
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